Southampton boss Ralph Hasenhüttl has confirmed that Lyanco will return to his squad ahead of the trip to Leicester City.
The Brazilian missed out on starting last weekend's draw with Leeds United at St Mary's with a knee injury, watching the game from the sidelines as an unused substitute.
But the manager has confirmed that his centre-back is now back in contention to start again ahead of his side's visit to the King Power Stadium on Saturday.
"Most players are okay," said Hasenhüttl, "Lyanco is back and available. The only problem was with Ché [Adams], he missed a few training sessions this week but was back in today and is available.
"There are other long-term injuries. Romain [Perraud] still not available like last game, Tino [Livramento] is also out for a long time.
"Theo [Walcott] is on his way back, he missed the whole of pre-season with injury but he's working to get back."