Ralph Hasenhüttl will be unable to call upon Moussa Djenepo for the trip to Everton on Thursday.
Completing a three-match suspension to return to the matchday squad on Sunday, the winger will now miss out with a calf injury that Hasenhüttl attributes to his extended break from match action.
“We have another injury with Moussa, which is not a conincidence for a player who has had a longer time off with a suspension.
“He’s had less training and games and sometimes this can lead to injuries during an intense programme like this.
“We have a few injuries, but I cannot say how many changes I will have to make. At the moment they’re all a little bit tired, but tomorrow we will look and decide who is and isn’t available to play.”
The manager confirmed other absentees for the trip to Goodision Park, although Pierre-Emile Højbjerg could play a part.
“Jannik [Vestergaard] will not make it with his quad injury, Sofiane [Boufal] is also still out and Yan Valery has a muscle injury still.
“Pierre [Højbjerg] is an option and could possibly make the bench.”