It’s the second Premier League International Cup fixture of the season for Southampton’s youngsters on Wednesday night as they face Monaco in Group F.
Saints’ last and only outing in the competition so far came at the end of October, where Feyenoord staged a second half revival to come away with the three points.
An own goal from the Dutch side had given Saints the lead in the 41st minute, but a second half comeback courtesy of goals from Noah Naujoks and Wouter Burger meant the visitors went away the happy side.
Saints’ defeat to Arsenal in Premier League 2 on Saturday was their first defeat in all competitions since the start of the month.
Meanwhile Monaco have had mixed fortunes in their International Cup adventure so far; losing their opening game 2-0 to Derby before beating Feyenoord 3-1.
Derby currently top Group F after having won both of their opening two games, whilst Monaco occupy second with three points from six.
Kick-off is at 7.00pm GMT at Staplewood on Tuesday night.
Remaining in cup action, the Under-23s will then turn attention to the Premier League Cup as AFC Bournemouth visit Snows Stadium on Monday 2nd December. Full details:free entry for premier league cup meeting with bournemouth