Southampton defender Wesley Hoedt helped Royal Antwerp inflict a first defeat of the season on Club Brugge in the result of the weekend in the Jupiler Pro League.
Hosts Antwerp trailed at half time, but fought back to level from the penalty spot through former Norwich and Hull striker Dieumerci Mbokani, before ex-Liverpool goalkeeper Simon Mignolet scored an unfortunate own goal to complete the turnaround.
Dutchman Hoedt played the full 90 minutes on his ninth appearance of the season for the Belgian club, as table-toppers Bruges saw their lead cut to five points.
In Scotland, Mohamed Elyounoussi and Fraser Forster were again instrumental as Celtic matched the result of fellow Scottish Premiership title hopefuls Rangers, with both clubs running out 2-0 winners on Sunday.
Forster kept his fourth successive clean sheet in the league as Odsonne Edouard and a second-half own goal helped Celtic ease past Motherwell to stay top on goal difference.
In Turkey, Mario Lemina played the full 90 minutes as Galatasaray won by the same scoreline at Gaziantep.
The reigning champions have not been at their vintage best this season, but are only two points off the top despite sitting in sixth position in a very congested Süper Lig.
Elsewhere on the continent, Guido Carrillo was a second-half substitute as new Léganes manager Javier Aguirre began his reign with a morale-boosting 1-1 draw at high-flying Real Sociedad.
Mexican boss Aguirre succeeds former Saints manager Mauricio Pellegrino at the Spanish club, who are rock bottom of La Liga.
Closer to home, Harrison Reed helped an inconsistent Fulham side get back to winning ways and remain in touch with the Championship promotion contenders thanks to a 1-0 victory at Birmingham, while there were a series of draws for the Saints loanees who were in FA Cup action.
Jake Hesketh played a starring role on only his second start of the season for Lincoln, but was left frustrated as his team missed the chance upset on League One leaders Ipswich.
The midfielder was involved in the opening goal, scored by Tyler Walker, as the Imps took a first-half lead at Portman Road, before winning a penalty that was saved, prompting Andre Dozzell to earn a replay for the Tractor Boys 11 minutes from time.
There was even later heartache for young goalkeeper Jack Rose, as Darlington of the National League North earned a share of the spoils seven minutes into added time at League Two Walsall.
Rose made a couple of notable saves in the match, but was powerless to prevent Joe Wheatley’s last-gasp leveller in one of the stories of the round.
Gillingham duo Alfie Jones and Tom O’Connor both played 90 minutes at Sunderland, as the Gills profited from a goalkeeping error in a 1-1 draw that ensures their name will be in the hat for the second round.
Another Saint hoping for a kind draw this evening is Marcus Barnes, who arrived off the bench to help spare Eastleigh’s blushes as Scott Rendell’s late equaliser prevented a shock defeat for the Spitfires at seventh-tier Stourbridge.