It's a trip to the Amex Stadium this weekend in the Premier League for Ralph Hasenhüttl's men...Can you name every Southampton goalscorer against Brighton since 2000? Test your knowledge below.
Quiz: Saints' opening day scorers
Test your memory of past season openers in this week's trivia.
Season Ticket holders: Update your details
Let us know if you are able to attend matches ahead of returning to St Mary’s.