Ralph Hasenhüttl has urged his players to seize the opportunity in front of them this Saturday and secure their Premier League status for next season.
Saints head into the weekend six points above the drop zone, and on the brink of ensuring safety, with a home game against Bournemouth awaiting them at St Mary's tomorrow.
Victory for them and anything other than a Cardiff win at Fulham would make relegation mathematically impossible, while a draw coupled with a loss for the Welsh club at Craven Cottage would also do the same.
ralph hasenhüttlthe players know this is a big chance, and the sooner we grab it the better.
However, the reality is that, with Saints' vastly superior goal difference to Cardiff, a win against Cherries would effectively remove any doubt about what division the team will be playing its football in next term, regardless of what happens elsewhere.
"Every game is a big opportunity to take three points," said Hasenhüttl. "We have an interesting game in our stadium, at St Mary's, and it's fantastic that we can make the last step to be sure and to be clear.
"In front of our crowd, it's fantastic, and that's what we want to have and we want to take this chance.
"We must be clear and motivated that this game at home we want to do everything to win it, and I think the players know this is a big chance and the sooner we grab it the better it is.
"We have two more games after, we know, but I think it is a good chance at home against Bournemouth to show another good performance like we did against Wolverhampton, and then I see a clear chance for us to take the three points.
"The players invested a lot in the last month and I think the development of the team was a good one, otherwise we wouldn't have the chance now to make us safe and that's the reason why I am very positive.
"You can see that the players try to push hard in this period. Three games in a week is massive, but after a very good second half against Newcastle we had 90 very good minutes against Watford, and the next game against Bournemouth is in the same style to play like we did against Wolverhampton – very aggressive, with good transition forward, and if you do so I think we have a big chance to take a win."