Get the lowdown on Jürgen Klopp's men from Liverpool Echo journalist James Pearce, as Saints prepare to take on the Premier League leaders at Anfield.
Five wins out of five so far in the Premier League this season, what would you put that start down to?
Liverpool have maintained the momentum they built up in the second half of last season which led them to the Champions League final and a second successive top-four Premier League finish.
Jürgen Klopp bought wisely this summer and the squad looks so strong. The Reds haven't been at their most potent or fluent going forward so far this term but they have been grinding out results.
Defensively, they have been outstanding with Joe Gomez shining alongside Virgil van Dijk. Confidence is sky high after back-to-back wins over Tottenham and Paris Saint-Germain.
A 3-2 victory over PSG in the Champions League as well, could we see Jurgen Klopp utilise his squad on Saturday and make changes?
Yes, it wouldn't surprise me if Klopp made three or four changes for the visit of Saints. It's been a gruelling week and they will need some fresh legs.
Naby Keita should come back into the midfield after being left out against PSG and fellow new boy Fabinho is another option. Roberto Firmino only came off the bench in midweek and he's likely to be back in the starting line up.
Klopp may also find room for Xherdan Shaqiri out wide, while Joel Matip is waiting for his chance in the back four.
Aside from the usual suspects, who has impressed you so far this season?
The front three grabbed all the headlines last season and deservedly so but it's been the defence and the midfield who have won games for Liverpool so far this season.
James Milner is in the form of his life and Gini Wijnaldum has also excelled in the middle of the park. The back four unit of Trent Alexander-Arnold, Gomez, Van Dijk and Andy Robertson has been so solid. Klopp has really addressed what was an area of weakness early on in his Anfield reign.
What sort of game are you expecting?
I think it will be tight. Liverpool haven't blown teams away so far this season and it will be difficult for them to replicate the tempo and intensity of the PSG game.
Saints will be fired up after throwing away that lead against Brighton. I can see the Reds edging it 2-1.