Cédric was an unused substitute as Portugal fell to a 3-0 defeat against the Netherlands at Stade de Genève.
After playing a pivotal role in their 2-1 victory over Egypt on Friday, the Saints full-back was rested for Joao Cancelo.
It took the Dutch just 11 minutes to open the scoring, when Brighton’s Davy Propper played an incisive through ball into Memphis Depay, who finished emphatically despite pressure from Jose Fonte inside the box.
On 38, they doubled the advantage when Matthijs de Ligt was set free down the right, before delivering a powerful cross that was headed home by Ryan Babel.
de Ligt got another assist in first-half injury time when he headed a free-kick back into a dangerous area for Virgil van Dijk to volley into the bottom corner.
The night got worse for Fernando Santos’s side when Cancelo was dismissed for a second bookable offence.