Claude Puel says it’s important his side recover quickly from defeat to Tottenham Hotspur at St Mary’s.
Saints were punished by their incisive visitors, with Nathan Redmond dismissed for a foul on Dele Alli with the game at 2-1.
Goals from Alli and Harry Kane turned the game on its head, before Son Heung-Min and the former of the England international pair sealed victory.
“It was difficult for us and it’s a bad scenario. Now it’s important for recovery and to react in another important game at home,” said Puel.
“We tried to come back. We had good opportunity with Højbjerg and Tadić which we could have done better to come back with a draw.
“It was difficult because they can counter attack and with every shot they score, but I’m happy with the spirit of our play.”