Ronald Koeman’s men make the midweek trip to north London looking to progress into the fourth round of the League Cup at the expense of the Gunners.
Saints are yet to win at the Emirates in the two matches they’ve played there, but they will take heart from the fact that Arsenal’s last domestic defeat on home soil was their 2-0 loss to Chelsea in the fourth round of last season's League Cup competition.
A first victory at the Emirates would give Saints five consecutive wins in all competitions - which would be their best run for over three years, a feat last achieved in the team’s promotion-winning season from the Championship.
Arsenal are unbeaten in their last 10 matches against Southampton in all competitions (won six, drawn four) since losing 3-2 at St Mary's in the Premier League in November 2002.
This is the fifth time the sides have been paired together in the League Cup. Arsenal advanced on all four previous occasions.
Saints have however, reached the fourth round of this competition in each of the last three seasons with the last two of those third round success coming with 2-0 victories.
Koeman will have new signing Sadio Mané available to him following the Senegalese forward’s arrival at the club’s training ground on Monday. His arrival is likely to see at least one change to the team that beat Swansea on Saturday.
Arsenal boss Arsène Wenger says he is without full-back Nacho Monreal and striker Yaya Sonogo, while Theo Walcott is not expected back until after the next international break
“They have done a fantastic job at Southampton, they deserve a lot of credit,” the Frenchman added.
“They are miracle-workers at Southampton and you must say everybody expected them to collapse, they lost the spine of their team, they lost their manager and they bounced back in such a way.”
Despite getting back to winning ways in the Barclays Premier League over the weekend, Wenger is likely to use the League Cup as an opportunity for his younger players to gain valuable match-experience.
“You might see Hector Bellerin, Francis Coquelin and Isaac Hayden,” Wenger also revealed on Monday. “In the squad, we also have Chuba Akpom and Semi Ajayi as well. These are the players that are the closest.”
Keith Stroud has been appointed as the referee for this game. Mr Stroud last took charge of a game involving Saints at the end of the 2008/09 season – a 3-1 defeat at Nottingham Forest which confirmed the team’s relegation from the Championship.