Saints play their second home game in the space of four days on Tuesday evening as we welcome Sheffield Wednesday in the Capital One Cup.
The third-round tie represents an opportunity to put together consecutive victories, with Nigel Adkins' side having earned their first Barclays Premier League points with a 4-1 win over Aston Villa on Saturday.
The visit of Wednesday, who won promotion to the npower Championship at the end of last season, also provides the chance for Saints to reach the last 16 for the second successive year.
Our opponents are presided over by Dave Jones, who spent three years as manager at The Dell between 1997 and 2000.
The Owls have not started the season as they might have hoped, and now sit fourth-bottom of the Championship standings after seven games.
They started well, progressing past Oldham and top-flight Fulham to reach round three of the Capital One Cup as well as seeing off Millwall and Birmingham in the league.
But four consecutive defeats has undone their good start, leaving Jones hoping his men can kick-start their campaign with victory at St Mary's.
Saints made 11 changes for the second-round win over Stevenage last month, and look likely to implement a similar amount of alterations against the Owls.
With the Under-21s' game against Spurs being postponed yesterday, Development Squad players such as Corby Moore, Jake Sinclair and Sam Hoskins will hope to be involved again having been on the bench at Stevenage.
Paulo Gazzaniga, fresh from his league debut in Saturday's win over Villa, will hope to start again while the likes of Danny Butterfield, Dan Seaborne and Luke Shaw will push for places in defence.
Jack Cork could make a First-Team return following his recovery from the ankle injury he suffered in pre-season, and Jay Rodriguez – the top goalscorer in the 2011-12 Carling Cup – could be handed a starting berth.
Wednesday will be without the cup-tied duo of Martin Taylor and Ross Barkley, while Rhys McCabe will miss out due to a thigh injury. Reda Johnson (ankle) and Jay Bothroyd (knee) are doubts.
Overall there have been 82 competitive meetings between Saints and Wednesday, with tomorrow's opponents having the better record.
Of those 82 matches, 25 have resulted in Southampton victories, 24 in draws and 33 have gone the way of the Owls.
We last met in League 1 in 2010-11, when we did the double over our Yorkshire opponents. Most recent was a 2-0 win at St Mary's in March 2011, secured courtesy of two goals in six minutes from José Fonte and Rickie Lambert.
Earlier that season, Saints won 1-0 at Hillsborough thanks to a Lee Barnard strike to secure the first win of Adkins' reign as manager exactly two years ago tomorrow.
Tomorrow's referee is Mark Halsey, who is assisted by D Bryan and M Wilkes. Simon Hooper is the fourth official.
Tickets remain on sale right up until kick off – you can buy from the ticket office, online or over the telephone on 02381 780780.
If scores are level at the end of 90 minutes, half-an-hour of extra time will be played. If no winner can be determined during that period, a penalty shootout will take place.
The draw for the fourth round will take place on Wednesday evening following the televised game between Manchester United and Newcastle United.
Assistant Manager Andy Crosby spoke to Saints Player ahead of tomorrow's game, so you can watch his one-on-one interview in full now.
There will be plenty more coverage following the game, too, with exclusive footage and interviews online soon after full time.