Adam Lallana says the Club's fans will have a big part to play if Saints are to get a result against Manchester United.
Having lost their first two games back in the Barclays Premier League, the hosts will go into this weekend's meeting with the Red Devils as underdogs.
United, meanwhile, were beaten in their season-opener away at Everton in a feisty encounter under the floodlights at Goodison Park.
And recently-appointed team captain Lallana says a sold-out St Mary's crowd could well inspire Saints to a similar result on Sunday.
"We've had a bit of a tough start, but I think the fans will get behind us so we can put in a good performance and get a result," Adam told Saints Player.
"If you look at the Everton game, they caused United a lot of problems. The fans were right on top of them and the atmosphere was great.
"If we can generate the same sort of atmosphere here on Sunday then I think we've got every chance.
"We'll give it our all because it's a game that we can get three points from and a result on our own patch.
"The fans will be a massive help and will count as a 12th man - it's different when you play these teams away from home, but you've got to capitalise when you get them in your own back yard.
"Manchester United at home is a massive, massive game and one you look for when the fixtures come out," he continued.
"It's only a short while ago that we were in League 1 and minus ten points, so it's been a quick transition and one we're proud of.
"It's games like Sunday's that leave you pinching yourself that we've come this far so quickly.
"Obviously, we'll be playing against world-class players but that's where you want to be performing and those are the players you want to be playing against.
"At Manchester City we proved a few critics wrong when we went 2-1 up after everyone wrote us off. We've got to do aim to do the same on Sunday."
A full one-on-one interview with Adam Lallana is on Saints Player now